New FAH results on possible new Alzheimer's drug presented

This is very preliminary news, but something I'm very, very excited about, so I'll give some advance news.  On Tuesday, we presented our results regarding new possible drugs (small molecule leads) to fight Alzheimer's Disease at a recent meeting at Stanford.  This meeting was part of the NIH Roadmap Nanomedicine center (http://proteinfoldingcenter.org/) retreat and was supported by NIH grants to Folding@home.

It's very early (so we are not publicly talking about the details until this has passed peer review), but we are very excited that it looks like we may have multiple small molecules which appear to inhibit toxicity of Abeta, the protein which is the toxic element in Alzheimer's Disease.

This is exciting in many ways.  It's been a long road for FAH to get to this point, but we are starting to see the possibility of seeing these results published easily before our 10th birthday (October 2010).  Considering all the technology development that had to be done in the first five years, these results have come very quickly (in the last 3 years), which is exciting.  In particular, we are now looking to apply these methods to other protein misfolding diseases (we have pilot projects for Huntington's Disease underway).

Finally, I should stress that while we're very excited about this, it's still early and a lot can go wrong between where we are and having a drug that doctors can prescribe.  Over the holidays, we will be double checking the experimental data, crossing t's and dotting i's to make sure there is nothing missed before we think about submitting this for peer reviewed publication.  Also, there is still a long way from an interesting possible drug (where we are now) to something which has passed FDA clinical trials (where we'd love to be), and a lot can go wrong in clinical trials in particular.  

Thus, this is an important milestone for FAH and we are very grateful to all who have contributed.  Happy holidays to all!

Comments

[Kyle]

Wow, awesome. It's incredibly exciting that the project might have already found a solution to one of the big problems it was designed to address.

Perhaps this could get even more people to contribute, as this result is more understandable to the general public than many of the other results so far (not saying that those're unimportant, but the results aren't exactly as eye-catching as "Alzheimer's might be cured").

[smASHer88]

I'm just glad to be involved.. whether u guys produce full-blown cures, or do the ground-work so that others can build on their research, i'm very happy to contribute to such a worthy project!

[Perl-Freak]

Just I know why I contribute thausends of WUs and got more than 1+ mio points.

I glad to hear that now results coming up.
Nice work and best christams gift for me.

[Michael G.R.]

Great news!

Sadly,the FDA bureaucracy is very good at delaying good cures, but hopefully it won't take too long this time if FAH has a winner on its hands.

[Elwal Vador]

Hopefuly Obama will appoint a faster, harder working, smarter FDA cheif who will trim some of the fat off the FDA and make it quicker at approving drugs.

[David]

Well done so far; looking forward to seeing results for Huntington's Disease.